Clomiphene (Clomid) — Dosing, Cycles, Half-Life & Side Effects
Clomiphene (Clomid) is a selective estrogen receptor modulator (SERM) with a half-life of 5-7 days (apparent); zuclomiphene enantiomer ~30 days. Selective estrogen receptor modulator for fertility and PCT. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | SERMs |
|---|---|
| Half-life | 5-7 days (apparent); zuclomiphene enantiomer ~30 days |
| Detection window | 60 days |
| Hepatotoxicity | None |
| Suppression | 0/10 |
| Administration | oral |
| US regulatory status | fda-approved |
Typical Dosing Ranges
Common dose range: 25-50mg/day (male PCT; Ibis 2026 cohort standard 25mg/day). FDA-labelled female ovulation induction is 50mg/day × 5 days — not a male-PCT reference.
Cycle length: 4-6 weeks
Time to steady state: ~25 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- Incompatible combinations per internal rule set: Enclomiphene, Tamoxifen (Nolvadex).
PCT Requirements
- Depot clearance estimate: ~25 days post-last-dose before SERM start (5 × apparent depot half-life of 120h).
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Mood changes
- Visual disturbances (scotomata, blurred vision) — dose-dependent and may persist after discontinuation
- Hot flashes
Known Interactions
HCG (Human Chorionic Gonadotropin) + Clomiphene (Clomid)
minor — hormonalHCG during PCT may interfere with SERM effectiveness by providing external LH signal.
Recommendation: Use HCG on-cycle or bridge, not during active PCT with SERMs.
Monitor: LH, FSH, Total testosterone
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Clomiphene (Clomid)?
Clomiphene (Clomid) has a half-life of approximately 5-7 days (apparent); zuclomiphene enantiomer ~30 days. Clearance estimate: 120h × 5 = 600h = 25 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Clomiphene (Clomid)?
Commonly reported ranges for Clomiphene (Clomid): 25-50mg/day (male PCT; Ibis 2026 cohort standard 25mg/day). FDA-labelled female ovulation induction is 50mg/day × 5 days — not a male-PCT reference.. Cycle length: 4-6 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Clomiphene (Clomid) suppress natural testosterone?
Clomiphene (Clomid) causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.
What is Clomiphene (Clomid) typically used for?
Clomiphene (Clomid) is commonly used for: PCT, Fertility, All experience levels. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Is Clomiphene (Clomid) legal?
Clomiphene (Clomid) is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.
Citations
- McBride JA, Coward RM. 2016. Asian J Androl — Racemic mixture half-life approximately 5 days
- İbis MA et al.. 2026. BJU International — Clomiphene citrate racemic mixture — zuclomiphene (slow-clearing enantiomer) t½ ~30 days; enclomiphene (active) t½ ~10 hours; supports weekly-to-daily dosing protocols
- Handelsman DJ / Shankara-Narayana N et al.. 2022. Eur J Endocrinol — HPTA recovery median 52 weeks post-AAS; informs SERM PCT duration rationale for clomiphene monotherapy or CC + hCG combined (not dual-SERM)
- Pharmacological class. 2018. J Clin Endocrinol Metab — Clomiphene is a SERM, not aromatized; aromatizationRate 0/10
- de Oliveira Vilar Neto JF et al.. 2021. Andrologia — Systematic review: only 4/38 known-outcome AAS-induced hypogonadism cases fully recovered; informs clomiphene monotherapy or CC + hCG combined PCT selection — observational data, NOT a dual-SERM recommendation (PROJECT.md constraint)
- McBride JA, Coward RM. Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl. 2016. (PCT dosing review)
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Clomiphene (Clomid). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.