Clomiphene (Clomid) — Dosing, Cycles, Half-Life & Side Effects

Clomiphene (Clomid) is a selective estrogen receptor modulator (SERM) with a half-life of 5-7 days (apparent); zuclomiphene enantiomer ~30 days. Selective estrogen receptor modulator for fertility and PCT. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.

Quick Facts

ClassSERMs
Half-life5-7 days (apparent); zuclomiphene enantiomer ~30 days
Detection window60 days
HepatotoxicityNone
Suppression0/10
Administrationoral
US regulatory statusfda-approved

Typical Dosing Ranges

Common dose range: 25-50mg/day (male PCT; Ibis 2026 cohort standard 25mg/day). FDA-labelled female ovulation induction is 50mg/day × 5 days — not a male-PCT reference.

Cycle length: 4-6 weeks

Time to steady state: ~25 days

Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.

Stacking Considerations

PCT Requirements

  • Depot clearance estimate: ~25 days post-last-dose before SERM start (5 × apparent depot half-life of 120h).
  • Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
  • Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.

Side Effect Profile

  • Mood changes
  • Visual disturbances (scotomata, blurred vision) — dose-dependent and may persist after discontinuation
  • Hot flashes

Known Interactions

  • HCG (Human Chorionic Gonadotropin) + Clomiphene (Clomid)

    minor — hormonal

    HCG during PCT may interfere with SERM effectiveness by providing external LH signal.

    Recommendation: Use HCG on-cycle or bridge, not during active PCT with SERMs.

    Monitor: LH, FSH, Total testosterone

Related compounds

Monitoring (Bloodwork & Vitals)

  • Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
  • Lipid panel (total cholesterol, HDL, LDL, triglycerides)
  • CBC (hemoglobin, hematocrit — watch for erythrocytosis)
  • Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
  • Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)

Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.

Frequently Asked Questions

What is the half-life of Clomiphene (Clomid)?

Clomiphene (Clomid) has a half-life of approximately 5-7 days (apparent); zuclomiphene enantiomer ~30 days. Clearance estimate: 120h × 5 = 600h = 25 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.

What is the typical dose range for Clomiphene (Clomid)?

Commonly reported ranges for Clomiphene (Clomid): 25-50mg/day (male PCT; Ibis 2026 cohort standard 25mg/day). FDA-labelled female ovulation induction is 50mg/day × 5 days — not a male-PCT reference.. Cycle length: 4-6 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.

Does Clomiphene (Clomid) suppress natural testosterone?

Clomiphene (Clomid) causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.

What is Clomiphene (Clomid) typically used for?

Clomiphene (Clomid) is commonly used for: PCT, Fertility, All experience levels. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.

Is Clomiphene (Clomid) legal?

Clomiphene (Clomid) is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.

Citations

  1. McBride JA, Coward RM. 2016. Asian J Androl — Racemic mixture half-life approximately 5 days
  2. İbis MA et al.. 2026. BJU International — Clomiphene citrate racemic mixture — zuclomiphene (slow-clearing enantiomer) t½ ~30 days; enclomiphene (active) t½ ~10 hours; supports weekly-to-daily dosing protocols
  3. Handelsman DJ / Shankara-Narayana N et al.. 2022. Eur J Endocrinol — HPTA recovery median 52 weeks post-AAS; informs SERM PCT duration rationale for clomiphene monotherapy or CC + hCG combined (not dual-SERM)
  4. Pharmacological class. 2018. J Clin Endocrinol Metab — Clomiphene is a SERM, not aromatized; aromatizationRate 0/10
  5. de Oliveira Vilar Neto JF et al.. 2021. Andrologia — Systematic review: only 4/38 known-outcome AAS-induced hypogonadism cases fully recovered; informs clomiphene monotherapy or CC + hCG combined PCT selection — observational data, NOT a dual-SERM recommendation (PROJECT.md constraint)
  6. McBride JA, Coward RM. Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian J Androl. 2016. (PCT dosing review)

Disclaimer

StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Clomiphene (Clomid). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.

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