Raloxifene — Dosing, Cycles, Half-Life & Side Effects

Raloxifene is a selective estrogen receptor modulator (SERM) with a half-life of 28 hours. Selective estrogen receptor modulator for bone health and PCT. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.

Quick Facts

ClassSERMs
Half-life28 hours
HepatotoxicityLow
Suppression0/10

Typical Dosing Ranges

Common dose range: 60mg/day

Cycle length: 4-6 weeks

Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.

Stacking Considerations

  • No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.

PCT Requirements

  • Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
  • Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.

Side Effect Profile

  • Expensive
  • Limited PCT use
  • Limited availability

Known Interactions

No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry.

Related compounds

Monitoring (Bloodwork & Vitals)

  • Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
  • Lipid panel (total cholesterol, HDL, LDL, triglycerides)
  • CBC (hemoglobin, hematocrit — watch for erythrocytosis)
  • Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
  • Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)

Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.

Frequently Asked Questions

What is the half-life of Raloxifene?

Raloxifene has a half-life of approximately 28 hours. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.

What is the typical dose range for Raloxifene?

Commonly reported ranges for Raloxifene: 60mg/day. Cycle length: 4-6 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.

Does Raloxifene suppress natural testosterone?

Raloxifene causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.

Is Raloxifene liver toxic?

Hepatotoxicity rating: Low. Non-17αα compound — liver stress is lower but still warrants periodic monitoring during a cycle.

What is Raloxifene typically used for?

Raloxifene is commonly used for: Bone health, PCT, All experience levels. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.

Citations

  1. FDA NDA 020815. 1997. FDA prescribing information — Raloxifene FDA-approved for osteoporosis and breast cancer risk reduction
  2. Ettinger B et al.. 1999. JAMA — MORE trial: raloxifene reduces vertebral fracture risk in postmenopausal women
  3. Plourde PV, et al. Safety and efficacy of anastrozole for gynecomastia. J Clin Endocrinol Metab. 2004;89(9):4428-33. PMID: 15356042
  4. Lawrence SE, et al. Raloxifene and tamoxifen in pubertal gynecomastia. J Pediatr. 2004;145(1):71-6. PMID: 15238910

Disclaimer

StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Raloxifene. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.

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