Superdrol (Methasterone) — Dosing, Cycles, Half-Life & Side Effects
Superdrol (Methasterone) is an oral anabolic-androgenic steroid with a half-life of 8-12 hours. Potent designer steroid for rapid mass and strength gains, highly hepatotoxic. Primary risks include significant hepatotoxicity, strong HPTA suppression, liver stress typical of 17α-alkylated orals. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Orals |
|---|---|
| Half-life | 8-12 hours |
| Detection window | 90 days |
| Aromatization | No |
| Hepatotoxicity | Very High |
| Suppression | 9/10 |
| 17α-alkylated | Yes |
| Administration | oral |
Typical Dosing Ranges
Common dose range: 10-30mg/day
Cycle length: 3-4 weeks
Time to steady state: ~2 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- Do not stack with another 17α-alkylated oral. Dual-17αα stacking is prohibited in StackItSmart and unsafe for the liver.
- Incompatible combinations per internal rule set: Anadrol (Oxymetholone), Dianabol (Methandrostenolone), Winstrol (Stanozolol), Anavar (Oxandrolone).
PCT Requirements
- This compound causes clinically meaningful HPTA suppression. Post-cycle therapy is recommended.
- Depot clearance estimate: ~2 days post-last-dose before SERM start (5 × apparent depot half-life of 8h).
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Severe hepatotoxicity
- Extreme suppression
- Methylated compound
- Harsh on lipids
Known Interactions
Superdrol (Methasterone) + Anavar (Oxandrolone)
major — hepatotoxicSuperdrol is extremely hepatotoxic. Any combination increases risk.
Recommendation: Superdrol should never be combined with other orals.
Monitor: Full liver panel every 3 days
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Liver enzymes (ALT, AST, GGT) every 2–4 weeks on oral 17αα cycles
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Superdrol (Methasterone)?
Superdrol (Methasterone) has a half-life of approximately 8-12 hours. Clearance estimate: 8h � 5 = 40h = 1.7 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Superdrol (Methasterone)?
Commonly reported ranges for Superdrol (Methasterone): 10-30mg/day. Cycle length: 3-4 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Superdrol (Methasterone) suppress natural testosterone?
Superdrol (Methasterone) causes severe suppression of the HPTA axis (score 9/10). Post-cycle therapy (PCT) is recommended after use.
Is Superdrol (Methasterone) liver toxic?
Hepatotoxicity rating: Very High. Superdrol (Methasterone) is 17α-alkylated, which bypasses first-pass liver metabolism and increases hepatic stress. Oral 17αα cycles should be capped at 6 weeks and paired with liver monitoring (ALT/AST every 2–4 weeks).
Does Superdrol (Methasterone) aromatize to estrogen?
Aromatization profile: No. Minimal to no aromatization expected, so aromatase inhibitors are not typically indicated for this compound alone.
What is Superdrol (Methasterone) typically used for?
Superdrol (Methasterone) is commonly used for: Bulking, Strength cycles, Advanced users only. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Citations
- DILI case series. 2020. Clinical case reports (multiple) — Half-life 8-9 hours for methyldrostanolone; among the most hepatotoxic oral AAS documented
- DILI case series. 2020. Clinical case reports — Cholestatic jaundice with bilirubin up to 50 mg/dL; 43% of cases showing kidney injury; peliosis hepatis reported
- Liu et al.. 2025. Substance Use & Misuse — AAS meta-analysis: SBP +12.43 mmHg (95% CI: 9.59-15.26), LDL-C +9.12 mg/dL (95% CI: 6.75-11.49)
- Abeles RD, Foxton M, Khan S et al.. 2020. BMJ Open Gastroenterol — RUCAM-causality systematic review of 52 AAS-DILI cases: methyldrostanolone (Superdrol) was the MOST COMMON offending agent. Peak bilirubin 705 μmol/L, 43% developed concurrent kidney injury, bland canalicular cholestasis on biopsy, bilirubin peaks ~28d after cessation
- Niedfeldt MW. 2018. Curr Sports Med Rep — 17α-alkylation slows hepatic clearance, causing elevated transaminases, acute cholestatic syndrome, peliosis hepatis, and hepatic tumors; methasterone among most hepatotoxic
- Kicman AT. 2008. Br J Pharmacol — Designer steroid 17α-alkyl modifications confer oral activity at cost of severe hepatic toxicity; methasterone (2α,17α-dimethyl-DHT) was a prohormone-era designer compound banned by 2012 Designer Anabolic Steroid Control Act
- Hartgens F, Kuipers H. 2004. Sports Med — Potent oral non-aromatizing AAS produce profound and rapid HPTA suppression; supports suppressionScore 9/10
- Kędzierski J, Allard JA, Odermatt A, Smieško M. 2023. Toxicol Lett — In vitro mechanism: methasterone (among 14 AAS tested) inhibits AKR1D1 (5β-reductase) — explains bile acid synthesis disruption underlying AAS cholestasis; mechanistic biology for cholestatic syndrome documented clinically
- Narayanan R, Coss CC, et al. Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways. Mol Endocrinol. 2008. PMID: 18801930
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Superdrol (Methasterone). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.