Follistatin 344 — Dosing, Cycles, Half-Life & Side Effects
Follistatin 344 is a growth-factor peptide with a half-life of Variable (hours to days depending on form). Naturally occurring protein that binds and inhibits myostatin (muscle growth inhibitor) and activin. By blocking myostatin, it may allow for enhanced muscle growth beyond normal genetic limits. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Growth Factors |
|---|---|
| Half-life | Variable (hours to days depending on form) |
| Hepatotoxicity | None |
| Suppression | 0/10 |
Typical Dosing Ranges
Common dose range: 100mcg/day for 10-30 days
Cycle length: 10-30 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Very expensive
- Limited human data
- Mechanism not fully validated in humans
- Quality and purity concerns
- May affect fertility (binds activin)
Known Interactions
No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry. Browse the full interaction matrix to cross-reference manually.
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Follistatin 344?
Follistatin 344 has a half-life of approximately Variable (hours to days depending on form). This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Follistatin 344?
Commonly reported ranges for Follistatin 344: 100mcg/day for 10-30 days. Cycle length: 10-30 days. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Follistatin 344 suppress natural testosterone?
Follistatin 344 causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.
What is Follistatin 344 typically used for?
Follistatin 344 is commonly used for: Muscle growth (experimental), Overcoming genetic limitations, Research. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Is Follistatin 344 legal?
Follistatin 344 is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.
Citations
- Kota J et al.. 2009. Sci Transl Med — Follistatin gene therapy for muscular dystrophy; limited human injectable data
- Lee SJ. Regulation of muscle mass by myostatin. Annu Rev Cell Dev Biol. 2004;20:61-86. PMID: 15473835
- Kota J, et al. Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Sci Transl Med. 2009;1(6):6ra15. PMID: 20368179
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Follistatin 344. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.