Andarine (S4) — Dosing, Cycles, Half-Life & Side Effects
Andarine (S4) is a selective androgen receptor modulator (SARM) with a half-life of 4-6 hours. SARM with partial agonist properties. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Selective Androgen Receptor Modulators |
|---|---|
| Half-life | 4-6 hours |
| Detection window | 7 days |
| Aromatization | No |
| Hepatotoxicity | Low |
| Suppression | 4/10 |
| 17α-alkylated | No |
| Administration | oral |
Typical Dosing Ranges
Common dose range: 25-75mg/day
Cycle length: 8-12 weeks
Time to steady state: ~1 days
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Depot clearance estimate: ~1 days post-last-dose before SERM start (5 × apparent depot half-life of 4h).
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Vision changes
- Short half-life
- Limited research
Known Interactions
No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry. Browse the full interaction matrix to cross-reference manually.
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Andarine (S4)?
Andarine (S4) has a half-life of approximately 4-6 hours. Clearance estimate: 4h × 5 = 20h = 1 day. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Andarine (S4)?
Commonly reported ranges for Andarine (S4): 25-75mg/day. Cycle length: 8-12 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Andarine (S4) suppress natural testosterone?
Andarine (S4) causes moderate suppression of the HPTA axis (score 4/10). PCT may still be advisable depending on stack and duration.
Is Andarine (S4) liver toxic?
Hepatotoxicity rating: Low. Non-17αα compound — liver stress is lower but still warrants periodic monitoring during a cycle.
Does Andarine (S4) aromatize to estrogen?
Aromatization profile: No. Minimal to no aromatization expected, so aromatase inhibitors are not typically indicated for this compound alone.
What is Andarine (S4) typically used for?
Andarine (S4) is commonly used for: Cutting, Fat loss, Beginner cycles. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Citations
- Kearbey JD et al.. 2004. Xenobiotica — Half-life 3-4 hours in rat; no human PK data available
- Gao W et al.. 2005. Endocrinology — HPTA effects in animal models; moderate suppression observed
- Perera MA et al.. 2006. Drug Metab Dispos — Andarine pharmacokinetics in dog model
- Gao W, et al. Selective androgen receptor modulator treatment improves muscle mass and strength, and reduces bone turnover in older men. J Clin Endocrinol Metab 2005
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Andarine (S4). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.