TB-500 (Thymosin Beta-4 Fragment) — Dosing, Cycles, Half-Life & Side Effects
TB-500 (Thymosin Beta-4 Fragment) is a tissue-repair peptide with a half-life of 7 days (due to extended tissue retention). Synthetic fragment of Thymosin Beta-4, a naturally occurring protein that regulates actin and promotes cell migration, wound healing, and tissue regeneration. Primarily researched for injury recovery and tissue repair. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Healing Peptides |
|---|---|
| Half-life | 7 days (due to extended tissue retention) |
| Hepatotoxicity | None |
| Suppression | 0/10 |
Typical Dosing Ranges
Common dose range: 2-5mg twice weekly (loading), then 2mg weekly (maintenance)
Cycle length: 4-8 weeks
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Limited human clinical trial data
- Not FDA approved
- WADA prohibited substance
- Requires injection
- Expensive
Known Interactions
bpc157 + tb500
minor — synergisticHealing peptides with complementary mechanisms.
Recommendation: Safe to combine. Often used together for injury recovery.
Monitor: None specific
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of TB-500 (Thymosin Beta-4 Fragment)?
TB-500 (Thymosin Beta-4 Fragment) has a half-life of approximately 7 days (due to extended tissue retention). This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for TB-500 (Thymosin Beta-4 Fragment)?
Commonly reported ranges for TB-500 (Thymosin Beta-4 Fragment): 2-5mg twice weekly (loading), then 2mg weekly (maintenance). Cycle length: 4-8 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does TB-500 (Thymosin Beta-4 Fragment) suppress natural testosterone?
TB-500 (Thymosin Beta-4 Fragment) causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.
What is TB-500 (Thymosin Beta-4 Fragment) typically used for?
TB-500 (Thymosin Beta-4 Fragment) is commonly used for: Injury recovery (experimental), Tissue repair, Joint and soft tissue support. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Is TB-500 (Thymosin Beta-4 Fragment) legal?
TB-500 (Thymosin Beta-4 Fragment) is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.
Citations
- Ruff D et al.. 2010. Ann N Y Acad Sci — Thymosin beta-4 Phase I safety data; fragment differs from full-length
- Cha HJ et al.. 2003. J Natl Cancer Inst — Thymosin beta-4 cancer promotion: 1.6x tumor size, 4.3x metastatic nodules
- Goldstein AL, et al. Thymosin beta4: a multi-functional regenerative peptide. Expert Opin Biol Ther. 2012;12(1):37-51. PMID: 22074294
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use TB-500 (Thymosin Beta-4 Fragment). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.