Sermorelin (GHRH 1-29) — Dosing, Cycles, Half-Life & Side Effects

Sermorelin (GHRH 1-29) is a growth hormone releasing hormone (GHRH) analogue with a half-life of 10-20 minutes. Bioidentical GHRH fragment (first 29 amino acids) that stimulates natural pulsatile GH release. FDA-approved for GH deficiency diagnosis and previously for pediatric GH deficiency treatment. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.

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Quick Facts

Class	Growth Hormone Releasing Hormone
Half-life	10-20 minutes
Hepatotoxicity	None
Suppression	0/10

Typical Dosing Ranges

Common dose range: 100-300mcg before bed

Cycle length: 12-26 weeks (long-term use acceptable)

Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.

Stacking Considerations

No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.

PCT Requirements

Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.

Side Effect Profile

Very short half-life
Requires nightly injection
Results take 3-6 months to manifest
Less potent than modified analogs

Known Interactions

No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry.

Monitoring (Bloodwork & Vitals)

Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
Lipid panel (total cholesterol, HDL, LDL, triglycerides)
CBC (hemoglobin, hematocrit — watch for erythrocytosis)
Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)

Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.

Frequently Asked Questions

What is the half-life of Sermorelin (GHRH 1-29)?

Sermorelin (GHRH 1-29) has a half-life of approximately 10-20 minutes. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.

What is the typical dose range for Sermorelin (GHRH 1-29)?

Commonly reported ranges for Sermorelin (GHRH 1-29): 100-300mcg before bed. Cycle length: 12-26 weeks (long-term use acceptable). These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.

Does Sermorelin (GHRH 1-29) suppress natural testosterone?

Sermorelin (GHRH 1-29) causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.

What is Sermorelin (GHRH 1-29) typically used for?

Sermorelin (GHRH 1-29) is commonly used for: Anti-aging protocols, Recovery enhancement, Sleep improvement. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.

Is Sermorelin (GHRH 1-29) legal?

Sermorelin (GHRH 1-29) is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.

Citations

FDA NDA 20-443. 1997. FDA prescribing information — FDA-approved 1990 diagnostic, 1997 therapeutic; half-life 11-12 minutes

Disclaimer

StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Sermorelin (GHRH 1-29). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.