Proviron (Mesterolone) — Dosing, Cycles, Half-Life & Side Effects

Proviron (Mesterolone) is an oral anabolic-androgenic steroid with a half-life of 12 hours. Mesterolone (1α-methyl-DHT) oral. NOT 17α-alkylated — therefore no cholestatic hepatotoxicity profile of 17αα orals. Approved in EU/UK (not US) for male infertility/hypogonadism. Binds SHBG (raising free testosterone) and competes with E2 at AR. Minimal anabolic effect; primarily used as anti-estrogenic adjunct. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.

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Quick Facts

Class	Orals
Half-life	12 hours
Detection window	42 days
Aromatization	No
Hepatotoxicity	None
Suppression	2/10
17α-alkylated	No
Administration	oral

Typical Dosing Ranges

Common dose range: 25-100mg/day

Cycle length: 8-12 weeks

Time to steady state: ~2.5 days

Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.

Stacking Considerations

No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.

PCT Requirements

Depot clearance estimate: ~3 days post-last-dose before SERM start (5 × apparent depot half-life of 12h).
Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.

Side Effect Profile

Limited anabolic effects
Hair loss risk
May worsen prostate
Not effective for mass

Known Interactions

No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry.

Monitoring (Bloodwork & Vitals)

Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
Lipid panel (total cholesterol, HDL, LDL, triglycerides)
CBC (hemoglobin, hematocrit — watch for erythrocytosis)
Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)

Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.

Frequently Asked Questions

What is the half-life of Proviron (Mesterolone)?

Proviron (Mesterolone) has a half-life of approximately 12 hours. Clearance estimate: 12h × 5 = 60h = 2.5 days. This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.

What is the typical dose range for Proviron (Mesterolone)?

Commonly reported ranges for Proviron (Mesterolone): 25-100mg/day. Cycle length: 8-12 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.

Does Proviron (Mesterolone) suppress natural testosterone?

Proviron (Mesterolone) causes minimal suppression of the HPTA axis (score 2/10). PCT may still be advisable depending on stack and duration.

Does Proviron (Mesterolone) aromatize to estrogen?

Aromatization profile: No. Minimal to no aromatization expected, so aromatase inhibitors are not typically indicated for this compound alone.

What is Proviron (Mesterolone) typically used for?

Proviron (Mesterolone) is commonly used for: Anti-estrogen, Libido support, Cutting cycles. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.

Citations

Disclaimer

StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Proviron (Mesterolone). Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.