Humanin — Dosing, Cycles, Half-Life & Side Effects
Humanin is a mitochondrial signalling peptide with a half-life of Variable (hours). Mitochondrial-derived peptide with cytoprotective and anti-apoptotic properties. Originally discovered for its ability to protect neurons from Alzheimer's-related toxicity. Has cardioprotective and metabolic benefits. This page is educational harm-reduction reference compiled from peer-reviewed literature — not medical advice, not an endorsement, not a recommendation to use. Consult a licensed clinician before any decision.
Quick Facts
| Class | Mitochondrial Peptides |
|---|---|
| Half-life | Variable (hours) |
| Hepatotoxicity | None |
| Suppression | 0/10 |
Typical Dosing Ranges
Common dose range: 1-5mg subcutaneous 2-3x/week (experimental)
Cycle length: 8-12 weeks
Dose ranges are compiled from published pharmacokinetic studies and community-reported usage. Where a value is community-reported rather than clinically studied, this page and its structured data flag it. Lower end of any range is always the safer starting point.
Stacking Considerations
- No structural stacking blockers. Standard harm-reduction rules apply: minimize total androgen load, minimize oral exposure, and monitor bloodwork.
PCT Requirements
- Never stack two SERMs. Extend a single SERM (tamoxifen OR enclomiphene/clomiphene) rather than combining.
- Use the cycle planner to generate a full protocol based on your complete stack, not this compound alone.
Side Effect Profile
- Very limited human clinical data
- Optimal dosing unknown
- Expensive
- Difficult to source
- Primarily research compound
Known Interactions
No compound-specific interactions are catalogued in the current matrix. This does not mean no risk exists — it means there is no curated pairwise entry. Browse the full interaction matrix to cross-reference manually.
Related compounds
Monitoring (Bloodwork & Vitals)
- Comprehensive metabolic panel (baseline, mid-cycle, post-cycle)
- Lipid panel (total cholesterol, HDL, LDL, triglycerides)
- CBC (hemoglobin, hematocrit — watch for erythrocytosis)
- Sex-hormone panel (Total T, Free T, Estradiol sensitive, SHBG, LH, FSH)
- Blood pressure (weekly self-check; flag systolic >140 or diastolic >90)
Baseline bloodwork is recommended before any cycle. Discontinue if liver enzymes exceed 3× upper limit of normal or if hematocrit exceeds 54%.
Frequently Asked Questions
What is the half-life of Humanin?
Humanin has a half-life of approximately Variable (hours). This figure is used to determine injection frequency (for esters) and post-cycle clearance timing.
What is the typical dose range for Humanin?
Commonly reported ranges for Humanin: 1-5mg subcutaneous 2-3x/week (experimental). Cycle length: 8-12 weeks. These are compiled from published studies and community-reported usage — individual response varies and lower end is always preferred.
Does Humanin suppress natural testosterone?
Humanin causes minimal suppression of the HPTA axis (score 0/10). PCT may still be advisable depending on stack and duration.
What is Humanin typically used for?
Humanin is commonly used for: Neuroprotection (experimental), Cardiac support, Longevity research, Metabolic support. Intended-use context does not imply safety — every use case carries the same underlying pharmacological risks.
Is Humanin legal?
Humanin is a controlled substance in many jurisdictions (typically Schedule III in the US when it is an anabolic androgenic steroid). StackItSmart does not provide sourcing information. Possession, import, and use without a prescription carry legal consequences that vary by country and state.
Citations
- Hashimoto Y et al.. 2001. Proc Natl Acad Sci USA — Humanin discovery as neuroprotective mitochondrial peptide; no human trials for PED use
- Hashimoto Y, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc Natl Acad Sci USA. 2001;98(11):6336-41. PMID: 11371646
- Muzumdar RH, et al. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009;4(7):e6334. PMID: 19623253
Disclaimer
StackItSmart is an independent harm-reduction reference. The content above is compiled from peer-reviewed literature and is not medical advice, not an endorsement, and not a recommendation to use Humanin. Performance-enhancing compounds carry legal, endocrine, cardiovascular, and hepatic risks. Consult a licensed clinician before any decision. StackItSmart does not provide sourcing, procurement, or dosing prescriptions.